Результаты работы являются экспериментальным обоснованием для клинических исследований фенсукцинала в качестве потенциального препарата для профилактики и лечения сахарного диабета и его сосудистых осложнений.
Ключевые слова: сахарный диабет, инсулинорезистентность, диабетические ангиопатии, фенсукцинал, производные янтарной кислоты, антиоксидант.
Gorbenko N.I. Pathogenic basis of succinic acid derivative – phensuccinal
efficacy in therapy of diabetes mellitus and its complications (experimental study).– Manuscript.
Thesis for the Degree of Doctor of Biological Sciences by speciality 14.01.14 – endocrinology. V. Danilevsky Institute of Endocrine Pathology Problems at AMS of Ukraine, Kharkiv, 2004.
The thesis is devoted to the study of complex antidiabetic properties of low-toxic succinic acid derivative – phensuccinal in experimental insulin deficiency, diabetic vascular pathology and different insulin resistant states. A new conception is substantiated according to which the theoretical and methodical background for the development of novel antidiabetic agents aimed not only at key factors of diabetes mellitus pathogenesis but at significant reduction of cardiovascular disease risk factors was created. It was proved that phensuccinal stimulated regeneration and secretion function of pancreatic beta-cells and protected ones from the destruction by diabetogenic agents. Administration of phensuccinal decreased geterogenous insulin resistance attenuated diabetic micro- and macroangiopathy development in absolute and relative insulin insufficiency. Possible molecular mechanisms of multifactorial antidibetic action of phensuccinal due to improvement of bioenergetics processes and suppression of oxidative stress in mitochondria and decrease of non-enzymatic glycosilation in diabetic animals were established. The results of investigation are used as theoretical substantiation of clinical trials of phensuccinal as potential pharmacological agent with complex antidiabetic properties.
Key words: diabetes mellitus, insulin resistance, diabetic angiopathy,
phensuccinal, succinic acid derivatives, antioxidant.